Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway

Precise regulation of DNA replication complex assembly requires cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) activities to activate the replicative helicase complex and initiate DNA replication. Chemical probes have been essential in the molecular analysis of DDK-mediated regulation...

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Detalles Bibliográficos
Autores principales: Pauzaite, Tekle, Tollitt, James, Sopaci, Betul, Caprani, Louise, Iwanowytsch, Olivia, Thacker, Urvi, Hardy, John G., Allinson, Sarah L., Copeland, Nikki A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405858/
https://www.ncbi.nlm.nih.gov/pubmed/36009559
http://dx.doi.org/10.3390/biomedicines10082012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405858/
https://www.ncbi.nlm.nih.gov/pubmed/36009559
http://dx.doi.org/10.3390/biomedicines10082012

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