Cargando…

Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway

Precise regulation of DNA replication complex assembly requires cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) activities to activate the replicative helicase complex and initiate DNA replication. Chemical probes have been essential in the molecular analysis of DDK-mediated regulation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pauzaite, Tekle, Tollitt, James, Sopaci, Betul, Caprani, Louise, Iwanowytsch, Olivia, Thacker, Urvi, Hardy, John G., Allinson, Sarah L., Copeland, Nikki A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405858/ https://www.ncbi.nlm.nih.gov/pubmed/36009559 http://dx.doi.org/10.3390/biomedicines10082012

Ejemplares similares

Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis
por: Pauzaite, Tekle, et al.
Publicado: (2016)

Identification of DHX9 as a cell cycle regulated nucleolar recruitment factor for CIZ1
por: Thacker, Urvi, et al.
Publicado: (2020)

The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds
por: Sasi, Nanda Kumar, et al.
Publicado: (2014)

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML
por: O’ Reilly, Eimear, et al.
Publicado: (2018)

Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo
por: Hou, Jue, et al.
Publicado: (2017)

Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness
por: Erbayraktar, Zubeyde, et al.
Publicado: (2016)

Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae
por: Eisenstatt, Jessica R., et al.
Publicado: (2020)

Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles
por: Rojas-Prats, Elisa, et al.
Publicado: (2021)

Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase
por: Cheng, Jiaxuan, et al.
Publicado: (2022)

DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7
por: De Jesús-Kim, Lorraine, et al.
Publicado: (2021)

CDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma
por: Martin, Jeffrey C., et al.
Publicado: (2022)

Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities
por: Gómez-Escoda, Blanca, et al.
Publicado: (2017)

A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication
por: Jares, Pedro, et al.
Publicado: (2004)

Cdc7p-Dbf4p Regulates Mitotic Exit by Inhibiting Polo Kinase
por: Miller, Charles T., et al.
Publicado: (2009)

The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4
por: Sheu, Yi-Jun, et al.
Publicado: (2010)

‘AND’ logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7
por: Almawi, Ahmad W., et al.
Publicado: (2016)

Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins
por: Zhang, Haiyang, et al.
Publicado: (2019)

DDK: The Outsourced Kinase of Chromosome Maintenance
por: Gillespie, Peter J., et al.
Publicado: (2022)

Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment
por: Natsume, Toyoaki, et al.
Publicado: (2013)

Author Correction: Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase
por: Cheng, Jiaxuan, et al.
Publicado: (2022)

Dbf2–Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis
por: Mohl, Dane A., et al.
Publicado: (2009)

Candida albicans Dbf4-dependent Cdc7 kinase plays a novel role in the inhibition of hyphal development
por: Lai, Wei-Chung, et al.
Publicado: (2016)

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
por: Saleh, Almutasem, et al.
Publicado: (2022)

Mechanisms Governing DDK Regulation of the Initiation of DNA Replication
por: Larasati,, et al.
Publicado: (2016)

Analysis of the expression and prognostic significance of DDK complex in Hepatocarcinoma
por: Wang, Min, et al.
Publicado: (2023)

DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
por: Sasi, Nanda Kumar, et al.
Publicado: (2017)

Rec8 Phosphorylation by Casein Kinase 1 and Cdc7-Dbf4 Kinase Regulates Cohesin Cleavage by Separase during Meiosis
por: Katis, Vittorio L., et al.
Publicado: (2010)

WEE1 Inhibition Augments CDC7 (DDK) Inhibitor–induced Cell Death in Ewing Sarcoma by Forcing Premature Mitotic Entry and Mitotic Catastrophe
por: Martin, Jeffrey C., et al.
Publicado: (2022)

Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach
por: Cheng, An Ning, et al.
Publicado: (2018)

Detection of CRISPR-Cas9-Mediated Mutations Using a Carbon Nanotube-Modified Electrochemical Genosensor
por: Kivrak, Ezgi, et al.
Publicado: (2021)

Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53
por: Abd Wahab, Syafiq, et al.
Publicado: (2020)

The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation
por: Volpi, Ilaria, et al.
Publicado: (2021)

Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase
por: Joseph, Chinnu Rose, et al.
Publicado: (2022)

Improving PHA production in a SBR of coupling PHA-storing microorganism enrichment and PHA accumulation by feed-on-demand control
por: Zeng, Shanwen, et al.
Publicado: (2018)

DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach
por: Wu, Kevin Z. L., et al.
Publicado: (2016)

Dihydro-5,6-dehydrokavain (DDK) from Alpinia zerumbet: Its Isolation, Synthesis, and Characterization
por: Xuan, Tran Dang, et al.
Publicado: (2015)

ATR–Chk1–APC/C(Cdh1)-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
por: Yamada, Masayuki, et al.
Publicado: (2013)

Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4
por: Nguyen, Tin, et al.
Publicado: (2012)

Structural Insights on PHA Binding Protein PhaP from Aeromonas hydrophila
por: Zhao, Hongyu, et al.
Publicado: (2016)

PHA Production and PHA Synthases of the Halophilic Bacterium Halomonas sp. SF2003
por: Thomas, Tatiana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2tk49optj1eh0heh0jrbr6v3g7