PT-112 Induces Mitochondrial Stress and Immunogenic Cell Death, Targeting Tumor Cells with Mitochondrial Deficiencies

SIMPLE SUMMARY: PT-112 is a novel pyrophosphate–platinum conjugate under Phase 1/2 clinical development for the treatment of several tumor types. In this study, using mouse tumor cells with well-characterized mitochondrial and metabolic status, we investigated the mechanisms underlying PT-112’s canc...

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Detalles Bibliográficos
Autores principales: Soler-Agesta, Ruth, Marco-Brualla, Joaquín, Minjárez-Sáenz, Martha, Yim, Christina Y., Martínez-Júlvez, Marta, Price, Matthew R., Moreno-Loshuertos, Raquel, Ames, Tyler D., Jimeno, José, Anel, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405950/
https://www.ncbi.nlm.nih.gov/pubmed/36010843
http://dx.doi.org/10.3390/cancers14163851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405950/
https://www.ncbi.nlm.nih.gov/pubmed/36010843
http://dx.doi.org/10.3390/cancers14163851

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