Cargando…

PT-112 Induces Mitochondrial Stress and Immunogenic Cell Death, Targeting Tumor Cells with Mitochondrial Deficiencies

SIMPLE SUMMARY: PT-112 is a novel pyrophosphate–platinum conjugate under Phase 1/2 clinical development for the treatment of several tumor types. In this study, using mouse tumor cells with well-characterized mitochondrial and metabolic status, we investigated the mechanisms underlying PT-112’s canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soler-Agesta, Ruth, Marco-Brualla, Joaquín, Minjárez-Sáenz, Martha, Yim, Christina Y., Martínez-Júlvez, Marta, Price, Matthew R., Moreno-Loshuertos, Raquel, Ames, Tyler D., Jimeno, José, Anel, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405950/ https://www.ncbi.nlm.nih.gov/pubmed/36010843 http://dx.doi.org/10.3390/cancers14163851

Ejemplares similares

Phase I study of PT-112, a novel pyrophosphate-platinum immunogenic cell death inducer, in advanced solid tumours
por: Karp, Daniel D., et al.
Publicado: (2022)

A Mutation in Mouse MT-ATP6 Gene Induces Respiration Defects and Opposed Effects on the Cell Tumorigenic Phenotype
por: Moreno-Loshuertos, Raquel, et al.
Publicado: (2023)

PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models
por: Yamazaki, Takahiro, et al.
Publicado: (2020)

Mutations in the ND2 Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells
por: Marco-Brualla, Joaquín, et al.
Publicado: (2019)

Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity
por: Soler-Agesta, Ruth, et al.
Publicado: (2022)

Mining the Flavoproteome of Brucella ovis, the Brucellosis Causing Agent in Ovis aries
por: Minjárez-Sáenz, Martha, et al.
Publicado: (2022)

DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL
por: Marco-Brualla, Joaquín, et al.
Publicado: (2023)

Mitochondrial genes in the 22q11.2 deleted region regulate neural stem and progenitor cell proliferation
por: Campbell, Philip D., et al.
Publicado: (2023)

Immunogenic Cell Death and Immunotherapy of Multiple Myeloma
por: Serrano-del Valle, Alfonso, et al.
Publicado: (2019)

Response: Commentary: Immunogenic Cell Death and Immunotherapy of Multiple Myeloma
por: Serrano Del Valle, Alfonso, et al.
Publicado: (2019)

Impaired Mitochondrial Folate Metabolism Reduces Mitochondrial Respiration in Mouse Muscle Progenitor Cells
por: Fiddler, Joanna, et al.
Publicado: (2022)

Local Temperature Increments and Induced Cell Death in Intracellular Magnetic Hyperthermia
por: Gu, Yuanyu, et al.
Publicado: (2023)

Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations
por: Moreno-Loshuertos, Raquel, et al.
Publicado: (2011)

Delaying Aging with Mitochondrial Micronutrients and Antioxidants
por: Ames, Bruce N., et al.
Publicado: (2001)

Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress
por: Yoon, Jimin, et al.
Publicado: (2023)

Mitochondrial metabolic reprogramming-mediated immunogenic cell death reveals immune and prognostic features of clear cell renal cell carcinoma
por: Yang, Lin, et al.
Publicado: (2023)

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment
por: Guerrero-Ochoa, Patricia, et al.
Publicado: (2022)

Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine
por: Fang, Chunju, et al.
Publicado: (2020)

Mutant Ubiquitin UBB+1 Induces Mitochondrial Fusion by Destabilizing Mitochondrial Fission-Specific Proteins and Confers Resistance to Oxidative Stress-Induced Cell Death in Astrocytic Cells
por: Yim, Nambin, et al.
Publicado: (2014)

In silico comparative analysis of GGDEF and EAL domain signaling proteins from the Azospirillum genomes
por: Mata, Alberto Ramírez, et al.
Publicado: (2018)

An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity
por: Miallot, Richard, et al.
Publicado: (2023)

Reciprocal Deletion and Duplication of 17p11.2-11.2: Korean Patients with Smith-Magenis Syndrome and Potocki-Lupski Syndrome
por: Lee, Cha Gon, et al.
Publicado: (2012)

Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia
por: Li, Jianping, et al.
Publicado: (2019)

The complete mitochondrial genome of the true limpet Scurria scurra (Lottiidae)
por: Saenz-Agudelo, Pablo
Publicado: (2022)

Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells
por: Woods, D. C.
Publicado: (2017)

Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance
por: Calvo, Tania, et al.
Publicado: (2020)

The Interaction between Circulating Cell-Free Mitochondrial DNA and Inflammatory Cytokines in Predicting Human Mental Health Issue Risk in Adolescents: An Explorative Study
por: Alatalo, Arto, et al.
Publicado: (2023)

Effect of nitric oxide on mitochondrial activity of human synovial cells
por: Cillero-Pastor, Berta, et al.
Publicado: (2011)

EXPRESSION OF THE MITOCHONDRIAL GENOME IN HELA CELLS : XV. Effect of Inhibition of Mitochondrial Protein Synthesis on Mitochondrial Formation
por: Storrie, Brian, et al.
Publicado: (1973)

Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus
por: Delavallée, Laure, et al.
Publicado: (2020)

Contribution of Mitochondrial DNA Heteroplasmy to the Congenital Cardiac and Palatal Phenotypic Variability in Maternally Transmitted 22q11.2 Deletion Syndrome
por: Rebolledo-Jaramillo, Boris, et al.
Publicado: (2021)

The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular Function
por: Xiu, Yuwen, et al.
Publicado: (2020)

High throughput single cell analysis of mitochondrial heteroplasmy in mitochondrial diseases
por: Maeda, Ryotaro, et al.
Publicado: (2020)

Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment
por: Maeda, Hideki, et al.
Publicado: (2021)

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
por: Zhang, Linlin, et al.
Publicado: (2022)

Democracia y procesos electorales /
por: Sánchez Agesta, Luis
Publicado: (1986)

Teoría y realidad en el conocimiento político
por: Sánchez Agesta, Luis
Publicado: (1944)

Curso de derecho constitucional comparado /
por: Sánchez Agesta, Luis
Publicado: (1974)

Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
por: Norat, Pedro, et al.
Publicado: (2020)

The metabolism of cells regulates their sensitivity to NK cells depending on p53 status
por: Belkahla, Sana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n3vpmfdmqrfh0so1a45aenautn