The Catalytic Domain Mediates Homomultimerization of MT1-MMP and the Prodomain Interferes with MT1-MMP Oligomeric Complex Assembly

Homomultimerization of MT1-MMP (membrane type 1 matrix metalloproteinase) through the hemopexin, transmembrane, and cytoplasmic domains plays a very important role in the activation of proMMP-2 and the degradation of pericellular collagen. MT1-MMP is overexpressed in many types of cancers, and it is...

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Detalles Bibliográficos
Autores principales: Fogarasi, Marton, Dima, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406036/
https://www.ncbi.nlm.nih.gov/pubmed/36009039
http://dx.doi.org/10.3390/biom12081145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406036/
https://www.ncbi.nlm.nih.gov/pubmed/36009039
http://dx.doi.org/10.3390/biom12081145

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