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HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas
Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of HOXA-cluster genes in 33% of patients. HOXA genes are master regulators of embryonic vascul...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406048/ https://www.ncbi.nlm.nih.gov/pubmed/36009018 http://dx.doi.org/10.3390/biom12081124 |
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author | Xie, Hongbo M. Bernt, Kathrin M. |
author_facet | Xie, Hongbo M. Bernt, Kathrin M. |
author_sort | Xie, Hongbo M. |
collection | PubMed |
description | Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of HOXA-cluster genes in 33% of patients. HOXA genes are master regulators of embryonic vascular development and adult neovascularization, which provides a molecular rationale to suspect that amplified HOXA genes act as oncogenes in angiosarcoma. HOXA amplifications typically affected multiple pro-angiogenic HOXA genes and co-occurred with amplifications of CD36 and KDR, whereas the overall mutation rate in these tumors was relatively low. HOXA amplifications were found most commonly in angiosarcomas located in the breast and were rare in angiosarcomas arising in sun-exposed areas on the head, neck, face and scalp. Our data suggest that HOXA-amplified angiosarcoma is a distinct molecular subgroup. Efforts to develop therapies targeting oncogenic HOX gene expression in AML and other sarcomas may have relevance for HOXA-amplified angiosarcoma. |
format | Online Article Text |
id | pubmed-9406048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94060482022-08-26 HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas Xie, Hongbo M. Bernt, Kathrin M. Biomolecules Brief Report Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of HOXA-cluster genes in 33% of patients. HOXA genes are master regulators of embryonic vascular development and adult neovascularization, which provides a molecular rationale to suspect that amplified HOXA genes act as oncogenes in angiosarcoma. HOXA amplifications typically affected multiple pro-angiogenic HOXA genes and co-occurred with amplifications of CD36 and KDR, whereas the overall mutation rate in these tumors was relatively low. HOXA amplifications were found most commonly in angiosarcomas located in the breast and were rare in angiosarcomas arising in sun-exposed areas on the head, neck, face and scalp. Our data suggest that HOXA-amplified angiosarcoma is a distinct molecular subgroup. Efforts to develop therapies targeting oncogenic HOX gene expression in AML and other sarcomas may have relevance for HOXA-amplified angiosarcoma. MDPI 2022-08-16 /pmc/articles/PMC9406048/ /pubmed/36009018 http://dx.doi.org/10.3390/biom12081124 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Xie, Hongbo M. Bernt, Kathrin M. HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
title | HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
title_full | HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
title_fullStr | HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
title_full_unstemmed | HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
title_short | HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas |
title_sort | hoxa amplification defines a genetically distinct subset of angiosarcomas |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406048/ https://www.ncbi.nlm.nih.gov/pubmed/36009018 http://dx.doi.org/10.3390/biom12081124 |
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