Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia

SIMPLE SUMMARY: The p210(BCR/ABL) oncoprotein is necessary and sufficient to trigger chronic myelogenous leukemia (CML) in mice. Our prior in vitro studies showing that the ABL-mediated phosphorylation of SOS1 promotes RAC activation and contributes to BCR-ABL leukemogenesis suggested the significan...

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Detalles Bibliográficos
Autores principales: Gómez, Carmela, Garcia-Navas, Rósula, Baltanás, Fernando C., Fuentes-Mateos, Rocío, Fernández-Medarde, Alberto, Calzada, Nuria, Santos, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406065/
https://www.ncbi.nlm.nih.gov/pubmed/36010887
http://dx.doi.org/10.3390/cancers14163893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406065/
https://www.ncbi.nlm.nih.gov/pubmed/36010887
http://dx.doi.org/10.3390/cancers14163893

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