3-Chloro-3-methyl-2,6-diarylpiperidin-4-ones as Anti-Cancer Agents: Synthesis, Biological Evaluation, Molecular Docking, and In Silico ADMET Prediction

Piperidine pharmacophore-containing compounds have demonstrated therapeutic efficacy against a range of diseases and are now being investigated in cancer. A series of 3-chloro-3-methyl-2,6-diarylpiperidin-4-ones, compounds (I–V) were designed and synthesized for their evaluation as a potential anti-...

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Detalles Bibliográficos
Autores principales: Ramalingam, Arulraj, Mustafa, Nurulhuda, Chng, Wee Joo, Medimagh, Mouna, Sambandam, Sivakumar, Issaoui, Noureddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406097/
https://www.ncbi.nlm.nih.gov/pubmed/36008987
http://dx.doi.org/10.3390/biom12081093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406097/
https://www.ncbi.nlm.nih.gov/pubmed/36008987
http://dx.doi.org/10.3390/biom12081093

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