Structure–Activity Relationship of the Dimeric and Oligomeric Forms of a Cytotoxic Biotherapeutic Based on Diphtheria Toxin

Protein aggregation is a well-recognized problem in industrial preparation, including biotherapeutics. These low-energy states constantly compete with a native-like conformation, which is more pronounced in the case of macromolecules of low stability in the solution. A better understanding of the st...

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Detalles Bibliográficos
Autores principales: Mielecki, Marcin, Ziemniak, Marcin, Ozga, Magdalena, Borowski, Radosław, Antosik, Jarosław, Kaczyńska, Angelika, Pająk, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406121/
https://www.ncbi.nlm.nih.gov/pubmed/36009005
http://dx.doi.org/10.3390/biom12081111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406121/
https://www.ncbi.nlm.nih.gov/pubmed/36009005
http://dx.doi.org/10.3390/biom12081111

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