The IGF-1R Inhibitor NVP-AEW541 Causes Insulin-Independent and Reversible Cardiac Contractile Dysfunction

The antitumor treatment NVP-AEW541 blocks IGF-1R. IGF-1R signaling is crucial for cardiac function, but the cardiac effects of NVP-AEW541 are ill defined. We assessed NVP-AEW541′s effects on cardiac function and insulin response in vivo and in isolated working hearts. We performed a dose–response an...

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Detalles Bibliográficos
Autores principales: Schenkl, Christina, Schrepper, Andrea, Heyne, Estelle, Doenst, Torsten, Schwarzer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406171/
https://www.ncbi.nlm.nih.gov/pubmed/36009569
http://dx.doi.org/10.3390/biomedicines10082022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406171/
https://www.ncbi.nlm.nih.gov/pubmed/36009569
http://dx.doi.org/10.3390/biomedicines10082022

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