SAR296968, a Novel Selective Na(+)/Ca(2+) Exchanger Inhibitor, Improves Ca(2+) Handling and Contractile Function in Human Atrial Cardiomyocytes

Background: In reverse-mode, cardiac sodium-calcium exchanger (NCX) can increase the cytoplasmic Ca(2+) concentration in response to high intracellular Na(+) levels, which may contribute to diastolic contractile dysfunction. Furthermore, increased spontaneous Ca(2+) release from intracellular stores...

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Detalles Bibliográficos
Autores principales: Hegner, Philipp, Drzymalski, Marzena, Biedermann, Alexander, Memmel, Bernadette, Durczok, Melanie, Wester, Michael, Floerchinger, Bernhard, Provaznik, Zdenek, Schmid, Christof, Zausig, York, Maier, Lars S., Wagner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406204/
https://www.ncbi.nlm.nih.gov/pubmed/36009478
http://dx.doi.org/10.3390/biomedicines10081932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406204/
https://www.ncbi.nlm.nih.gov/pubmed/36009478
http://dx.doi.org/10.3390/biomedicines10081932

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