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Programmable antivirals to target conserved essential shapes in pandemic viral genomes
We identified and mapped at high-resolution RNA structures in viral genomes that are essential for virus reproduction. We then rapidly designed potent antivirals with high barriers to resistance that prevent or treat severe infections of these viruses with pandemic potential — via development of wha...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406275/ https://www.ncbi.nlm.nih.gov/pubmed/36008723 http://dx.doi.org/10.1038/s41591-022-01910-3 |