Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes

The m.3243A>G mutation in mitochondrial tRNA-Leu(UUR) is one of the most common pathogenic mitochondrial DNA mutations in humans. The clinical manifestations are highly heterogenous and the causes for the drastic clinical variability are unknown. Approximately one third of patients suffer from ca...

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Detalles Bibliográficos
Autores principales: Ryytty, Sanna, Modi, Shalem R., Naumenko, Nikolay, Shakirzyanova, Anastasia, Rahman, Muhammad Obaidur, Vaara, Miia, Suomalainen, Anu, Tavi, Pasi, Hämäläinen, Riikka H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406376/
https://www.ncbi.nlm.nih.gov/pubmed/36010669
http://dx.doi.org/10.3390/cells11162593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406376/
https://www.ncbi.nlm.nih.gov/pubmed/36010669
http://dx.doi.org/10.3390/cells11162593

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