Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy

SIMPLE SUMMARY: TP53 is the most frequently mutated gene in many cancers, but it has failed to be a very effective target for treatment to date. To overcome this, we have examined what else changes in cells when the TP53 gene is mutated. We modified cells that had no TP53 expression to have one of t...

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Detalles Bibliográficos
Autores principales: Vadakekolathu, Jayakumar, Boocock, David J., Pandey, Kirti, Guinn, Barbara-ann, Legrand, Antoine, Miles, Amanda K., Coveney, Clare, Ayala, Rochelle, Purcell, Anthony W., McArdle, Stephanie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406384/
https://www.ncbi.nlm.nih.gov/pubmed/36010968
http://dx.doi.org/10.3390/cancers14163975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406384/
https://www.ncbi.nlm.nih.gov/pubmed/36010968
http://dx.doi.org/10.3390/cancers14163975

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