Cargando…

Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer?

SIMPLE SUMMARY: Dynamic chromatin remodeling is regulated by different epigenetic modifications of histones to adapt chromatin to specific cellular functions. Targeting histone epigenetic enzymes will interfere with the correct mechanisms of DNA repair. Therefore, targeting epigenetic enzymes is a p...

Descripción completa

Detalles Bibliográficos
Autor principal:	Lazo, Pedro A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406467/ https://www.ncbi.nlm.nih.gov/pubmed/36011043 http://dx.doi.org/10.3390/cancers14164050

Ejemplares similares

Epigenetic based synthetic lethal strategies in human cancers
por: Gao, Aiai, et al.
Publicado: (2020)

Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response
por: Das, Shaoli, et al.
Publicado: (2019)

Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy
por: Campillo-Marcos, Ignacio, et al.
Publicado: (2021)

Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response
por: Pinoli, Pietro, et al.
Publicado: (2021)

Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response
por: Kciuk, Mateusz, et al.
Publicado: (2022)

Epigenetic connection between gut microbiota-derived short-chain fatty acids and chromatin histone modification in kidney diseases
por: Li, Lingzhi, et al.
Publicado: (2022)

Histone post-translational modification and the DNA damage response
por: Song, Haoyun, et al.
Publicado: (2022)

Epigenetic synthetic lethality approaches in cancer therapy
por: Yang, Haoshen, et al.
Publicado: (2019)

Epigenetic modifications of histones in cancer
por: Zhao, Zibo, et al.
Publicado: (2019)

Evolving DNA repair synthetic lethality targets in cancer
por: Kulkarni, Sanat, et al.
Publicado: (2022)

Role of RNA modifications in carcinogenesis and carcinogen damage response
por: Verghese, Michelle, et al.
Publicado: (2022)

Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
por: Mandal, Jayaprakash, et al.
Publicado: (2022)

The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease
por: Kourtidou, Christodoula, et al.
Publicado: (2023)

APE2: catalytic function and synthetic lethality draw attention as a cancer therapy target
por: McMahon, Anne, et al.
Publicado: (2023)

Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
por: Mast, Fred D., et al.
Publicado: (2020)

Cell Death Response to DNA Damage
por: Wang, Jean Y. J.
Publicado: (2019)

Targeting the epigenetics of the DNA damage response in breast cancer
por: Montenegro, M F, et al.
Publicado: (2016)

Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461
por: Masud, Tehmina, et al.
Publicado: (2021)

Epigenetic Cross-Talk between DNA Methylation and Histone Modifications in Human Cancers
por: Kondo, Yutaka
Publicado: (2009)

Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response
por: Lopez, Karla E., et al.
Publicado: (2022)

DNA repair and synthetic lethality
por: Guo, Gong-she, et al.
Publicado: (2011)

Epigenetic Modifications: An Unexplored Facet of Exogenous RNA Application in Plants
por: Dalakouras, Athanasios, et al.
Publicado: (2020)

A New Epigenetic Crosstalk: Chemical Modification Information Flow
por: Lee, Hongwoo, et al.
Publicado: (2023)

The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
por: Monte-Serrano, Eva, et al.
Publicado: (2023)

Synthetic Lethal Drug Combinations Targeting Proteasome and Histone Deacetylase Inhibitors in TP53-Mutated Cancers
por: Das, Shaoli, et al.
Publicado: (2020)

Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification
por: Wu, Dan, et al.
Publicado: (2023)

VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells
por: Navarro-Carrasco, Elena, et al.
Publicado: (2021)

Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers
por: Bhaskara, Srividya
Publicado: (2015)

Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer
por: Wicha, Max S
Publicado: (2009)

Doxycycline and therapeutic targeting of the DNA damage response in cancer cells: old drug, new purpose
por: Peiris-Pagès, Maria, et al.
Publicado: (2015)

Sex disparities in DNA damage response pathways: Novel determinants in cancer formation and therapy
por: Cardano, Miriana, et al.
Publicado: (2022)

Overview of Ferroptosis and Synthetic Lethality Strategies
por: Kinowaki, Yuko, et al.
Publicado: (2021)

Linking the epigenetic ‘language’ of covalent histone modifications to cancer
por: Hake, S B, et al.
Publicado: (2004)

PPARs as determinants of the estrogen receptor lineage: use of synthetic lethality for the treatment of estrogen receptor-negative breast cancer
por: Glazer, Robert I., et al.
Publicado: (2017)

Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance
por: Vainshelbaum, Ninel Miriam, et al.
Publicado: (2022)

Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches
por: Lazo, John S.
Publicado: (2018)

Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification
por: Yang, Qingfan, et al.
Publicado: (2022)

The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review
por: Persaud, Nikita S., et al.
Publicado: (2023)

Harnessing Epigenetics for Breast Cancer Therapy: The Role of DNA Methylation, Histone Modifications, and MicroRNA
por: Szczepanek, Joanna, et al.
Publicado: (2023)

Modification of Epigenetic Histone Acetylation in Hepatocellular Carcinoma
por: Liu, Kwei-Yan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_63odnlsf2fgc3hor98stfvhbbs