2,4-Diacetylphloroglucinol Reduces Beta-Amyloid Production and Secretion by Regulating ADAM10 and Intracellular Trafficking in Cellular and Animal Models of Alzheimer’s Disease

There is currently no effective treatment against Alzheimer’s disease (AD), although many strategies have been applied to reduce beta-amyloid (Aβ) levels. Here, we investigated 2,4-diacetylphloroglucinol (DAPG) effects on Aβ levels and mechanisms of action. DAPG was the most effective phloroglucinol...

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Detalles Bibliográficos
Autores principales: Jang, Bong-Geum, Choi, Boyoung, Kim, Suyeon, Lee, Duk-Shin, Lee, Jisun, Koh, Young Ho, Jo, Sangmee Ahn, Kim, Ji-Eun, Kang, Tae-Cheon, Kim, Min-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406471/
https://www.ncbi.nlm.nih.gov/pubmed/36010661
http://dx.doi.org/10.3390/cells11162585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406471/
https://www.ncbi.nlm.nih.gov/pubmed/36010661
http://dx.doi.org/10.3390/cells11162585

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