Modulation of Fibroblast Phenotype by Colorectal Cancer Cell-Secreted Factors Is Mostly Independent of Oncogenic KRAS

KRAS mutations have been shown to extend their oncogenic effects beyond the cancer cell, influencing the tumor microenvironment. Herein, we studied the impact of mutant KRAS on the modulation of the pro-tumorigenic properties of cancer-associated fibroblasts (CAFs), including α-SMA expression, TGFβ1...

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Detalles Bibliográficos
Autores principales: Dias Carvalho, Patrícia, Mendonça, Susana, Martins, Flávia, Oliveira, Maria José, Velho, Sérgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406506/
https://www.ncbi.nlm.nih.gov/pubmed/36010567
http://dx.doi.org/10.3390/cells11162490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406506/
https://www.ncbi.nlm.nih.gov/pubmed/36010567
http://dx.doi.org/10.3390/cells11162490

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