Targeted Long-Read Bisulfite Sequencing Identifies Differences in the TERT Promoter Methylation Profiles between TERT Wild-Type and TERT Mutant Cancer Cells

SIMPLE SUMMARY: TERT promoter methylation is enriched in cancers lacking TERT genetic alterations (wild-type cancers), but its functional impact on TERT transcription remains elusive. We developed a long-read bisulfite-sequencing platform to characterize the TERT promoter methylation profile at a si...

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Detalles Bibliográficos
Autores principales: Lee, Seungjae, Chang, Ti-Cheng, Schreiner, Patrick, Fan, Yiping, Agarwal, Neeraj, Owens, Charles, Dummer, Reinhard, Kirkwood, John M., Barnhill, Raymond L., Theodorescu, Dan, Wu, Gang, Bahrami, Armita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406525/
https://www.ncbi.nlm.nih.gov/pubmed/36011010
http://dx.doi.org/10.3390/cancers14164018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406525/
https://www.ncbi.nlm.nih.gov/pubmed/36011010
http://dx.doi.org/10.3390/cancers14164018

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