Cargando…

Development of Novel Therapeutics for Schizophrenia Treatment Based on a Selective Positive Allosteric Modulation of α1-Containing GABAARs—In Silico Approach

For the development of atypical antipsychotics, the selective positive allosteric modulation of the ionotropic GABAA receptor (GABAAR) has emerged as a promising approach. In the presented research, two unrelated methods were used for the development of QSAR models for selective positive allosteric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Đorđević, Vladimir, Petković, Milan, Živković, Jelena, Nikolić, Goran M., Veselinović, Aleksandar M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406691/ https://www.ncbi.nlm.nih.gov/pubmed/36005130 http://dx.doi.org/10.3390/cimb44080234

Ejemplares similares

Downregulation of GABAARα1 Aggravates Comorbidity of Epilepsy and Migraine via the TLR4 Signaling Pathway
por: Lin, Yao, et al.
Publicado: (2022)

Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy
por: Tang, Shirong, et al.
Publicado: (2017)

KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia
por: Gao, Yuan, et al.
Publicado: (2022)

Decreased Activity of Erythrocyte Catalase and Glutathione Peroxidase in Patients with Schizophrenia
por: Djordjević, Vladimir V., et al.
Publicado: (2022)

Role of GABAAR in the Transition From Acute to Chronic Pain and the Analgesic Effect of Electroacupuncture on Hyperalgesic Priming Model Rats
por: Wang, Sisi, et al.
Publicado: (2021)

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
por: Costa-Machado, Luis Filipe, et al.
Publicado: (2023)

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator
por: Piantadosi, Sean C., et al.
Publicado: (2016)

In silico approach for the development of novel antiviral compounds based on SARS-COV-2 protease inhibition
por: Ničkčović, Vanja P., et al.
Publicado: (2022)

Modulatory Actions of the Glycine Receptor β Subunit on the Positive Allosteric Modulation of Ethanol in α2 Containing Receptors
por: Muñoz, Braulio, et al.
Publicado: (2021)

In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator
por: D’Aniello, Enrico, et al.
Publicado: (2019)

Anxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Rats
por: Islas-Preciado, Dannia, et al.
Publicado: (2022)

GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex
por: Bogaj, Karolina, et al.
Publicado: (2023)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies
por: Bartuzi, Damian, et al.
Publicado: (2020)

Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats
por: Nikiforuk, Agnieszka, et al.
Publicado: (2020)

Gabrb2 knock-out mice exhibit double-directed PMDD-like symptoms: GABAAR subunits, neurotransmitter metabolism disruption, and allopregnanolone binding
por: Gao, Mingzhou, et al.
Publicado: (2022)

In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators
por: Yuan, Jiayi, et al.
Publicado: (2022)

Identification of Oleanolic Acid as Allosteric Agonist of Integrin α(M) by Combination of In Silico Modeling and In Vitro Analysis
por: Jin, Lu, et al.
Publicado: (2021)

Widespread Changes in Positive Allosteric Modulation of the Muscarinic M(1) Receptor in Some Participants With Schizophrenia
por: Hopper, Shaun, et al.
Publicado: (2019)

Characterization of a novel positive allosteric modulator of the α(1A)-Adrenergic receptor
por: Papay, Robert S., et al.
Publicado: (2022)

In silico study on identification of novel MALT1 allosteric inhibitors
por: Zhang, Jinrui, et al.
Publicado: (2019)

In Silico Study of Allosteric Communication Networks in GPCR Signaling Bias
por: Morales-Pastor, Adrian, et al.
Publicado: (2022)

Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage
por: Wang, Tongtong, et al.
Publicado: (2020)

Antimicrobial Activity of Nitrogen-Containing 5-α-Androstane Derivatives: In Silico and Experimental Studies
por: Amiranashvili, Lela, et al.
Publicado: (2020)

Effect of mGluR2 Positive Allosteric Modulation on Frontostriatal Working Memory Activation in Schizophrenia
por: Wolf, Daniel H., et al.
Publicado: (2022)

Oxidative Stress Mediated Therapy in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
por: Djordjevic, Katarina, et al.
Publicado: (2023)

Retraction: Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage
Publicado: (2022)

Progress and Pitfalls in Developing Agents to Treat Neurocognitive Deficits Associated with Schizophrenia
por: Veselinović, Tanja, et al.
Publicado: (2022)

In silico analysis of Glanzmann variants of Calf-1 domain of α(IIb)β(3) integrin revealed dynamic allosteric effect
por: Goguet, Matthieu, et al.
Publicado: (2017)

Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-Activated Protein Kinase (MAPK) at the Allosteric Site
por: Suriya, Utid, et al.
Publicado: (2022)

Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABA(A) receptors, in a mouse model of Dravet syndrome
por: Nakakubo, Sachiko, et al.
Publicado: (2023)

Comparing Anxiety Levels during the COVID-19 Pandemic among Mothers of Children with and without Neurodevelopmental Disorders
por: Bogavac, Ivana, et al.
Publicado: (2023)

Increased Cortical Porosity, Reduced Cortical Thickness, and Reduced Trabecular and Cortical Microhardness of the Superolateral Femoral Neck Confer the Increased Hip Fracture Risk in Individuals with Type 2 Diabetes
por: Cirovic, Aleksandar, et al.
Publicado: (2022)

Influence of antipsychotics on metabolic syndrome risk in patients with schizophrenia
por: Koricanac, Aleksandra, et al.
Publicado: (2022)

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Li, Qimeng, et al.
Publicado: (2023)

Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies
por: Elshaflu, Hana, et al.
Publicado: (2018)

The Role of Lipids in Allosteric Modulation of Dopamine D(2) Receptor—In Silico Study
por: Żuk, Justyna, et al.
Publicado: (2022)

Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation
por: Díaz, Oscar, et al.
Publicado: (2022)

Synthesis, In Silico, and In Vitro Evaluation of Anti-Leishmanial Activity of Oxadiazoles and Indolizine Containing Compounds Flagged against Anti-Targets
por: Stevanovic, Strahinja, et al.
Publicado: (2019)

Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches
por: Shinde, Ranajit Nivrutti, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_kfapkd2k5favfsdl6t3nk0kv5n