The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence

HIGHLIGHTS: Deregulation in MMR mechanism and miR-21, miR-155 and miR-451a are caused by chronic exposure to N-Nitrosamines, NNK and NDEA, and nicotine. Reduced hMSH2 and hMLH1 gene expression profiles and miRNA deregulations can be detected both at early stages of tobacco smoke-related carcinogenes...

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Detalles Bibliográficos
Autores principales: Doukas, Sotirios G., Vageli, Dimitra P., Doukas, Panagiotis G., Nikitovic, Dragana, Tsatsakis, Aristidis, Judson, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406897/
https://www.ncbi.nlm.nih.gov/pubmed/36005175
http://dx.doi.org/10.3390/curroncol29080437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406897/
https://www.ncbi.nlm.nih.gov/pubmed/36005175
http://dx.doi.org/10.3390/curroncol29080437

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