Combination of dl922-947 Oncolytic Adenovirus and G-Quadruplex Binders Uncovers Improved Antitumor Activity in Breast Cancer

G-quadruplexes (G4s) are nucleic secondary structures characterized by G-tetrads. G4 motif stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small molecules are the focus of clinical investigation. DNA destabilization induced by G4 ligands might potentiate the anticance...

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Detalles Bibliográficos
Autores principales: Napolitano, Fabiana, Di Somma, Sarah, Castellano, Giuliano, Amato, Jussara, Pagano, Bruno, Randazzo, Antonio, Portella, Giuseppe, Malfitano, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406944/
https://www.ncbi.nlm.nih.gov/pubmed/36010559
http://dx.doi.org/10.3390/cells11162482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406944/
https://www.ncbi.nlm.nih.gov/pubmed/36010559
http://dx.doi.org/10.3390/cells11162482

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