A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo

Jumonji C-domain-containing protein 6 (JMJD6), an iron (Fe(2+)) and α-ketoglutarate (α-KG)-dependent oxygenase, is expressed at high levels, correlated with poor prognosis, and considered as a therapeutic target in multiple cancer types. However, specific JMJD6 inhibitors that are potent in suppress...

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Detalles Bibliográficos
Autores principales: Xiao, Rong-quan, Ran, Ting, Huang, Qi-xuan, Hu, Guo-sheng, Fan, Da-meng, Yi, Jia, Liu, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407455/
https://www.ncbi.nlm.nih.gov/pubmed/35969736
http://dx.doi.org/10.1073/pnas.2200753119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407455/
https://www.ncbi.nlm.nih.gov/pubmed/35969736
http://dx.doi.org/10.1073/pnas.2200753119

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