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Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter

The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the survival of pathogenic bacteria under extreme acid stress by exchanging extracellular glutamate for intracellular γ-aminobutyric acid (GABA). Its structure, determined in an inward-facing conformation at alkaline pH, con...

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Detalles Bibliográficos
Autores principales: del Alamo, Diego, DeSousa, Lillian, Nair, Rahul M., Rahman, Suhaila, Meiler, Jens, Mchaourab, Hassane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407458/
https://www.ncbi.nlm.nih.gov/pubmed/35969794
http://dx.doi.org/10.1073/pnas.2206129119