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Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter
The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the survival of pathogenic bacteria under extreme acid stress by exchanging extracellular glutamate for intracellular γ-aminobutyric acid (GABA). Its structure, determined in an inward-facing conformation at alkaline pH, con...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407458/ https://www.ncbi.nlm.nih.gov/pubmed/35969794 http://dx.doi.org/10.1073/pnas.2206129119 |