A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function

Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading cause of enterically transmitted viral hepatitis worldwide. Ribavirin (RBV) is currently the only treatment option for many patients; however, cases of treatment failures or posttreatment relapses have been fr...

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Detalles Bibliográficos
Autores principales: Meister, Toni Luise, Brüggemann, Yannick, Nocke, Maximilian K., Ulrich, Rainer G., Schuhenn, Jonas, Sutter, Kathrin, Gömer, André, Bader, Verian, Winklhofer, Konstanze F., Broering, Ruth, Verhoye, Lieven, Meuleman, Philip, Vondran, Florian W. R., Camuzet, Charline, Cocquerel, Laurence, Todt, Daniel, Steinmann, Eike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407633/
https://www.ncbi.nlm.nih.gov/pubmed/35969792
http://dx.doi.org/10.1073/pnas.2202653119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407633/
https://www.ncbi.nlm.nih.gov/pubmed/35969792
http://dx.doi.org/10.1073/pnas.2202653119

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