ThnL, a B12-dependent radical S-adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis

Complex carbapenems are important clinical antibiotics used to treat recalcitrant infections. Their biosynthetic gene clusters contain three essential B(12)-dependent radical S-adenosylmethionine (rSAM) enzymes. The majority of characterized enzymes in this subfamily catalyze methyl transfer, but on...

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Detalles Bibliográficos
Autores principales: Sinner, Erica K., Li, Rongfeng, Marous, Daniel R., Townsend, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407657/
https://www.ncbi.nlm.nih.gov/pubmed/35969793
http://dx.doi.org/10.1073/pnas.2206494119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407657/
https://www.ncbi.nlm.nih.gov/pubmed/35969793
http://dx.doi.org/10.1073/pnas.2206494119

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