Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

Tau protein aggregates are a major driver of neurodegeneration and behavioral impairments in tauopathies, including in Alzheimer’s disease (AD). Apolipoprotein E4 (APOE4), the highest genetic risk factor for late-onset AD, has been shown to exacerbate tau hyperphosphorylation in mouse models. Howeve...

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Detalles Bibliográficos
Autores principales: Saroja, Sivaprakasam R., Gorbachev, Kirill, TCW, Julia, Goate, Alison M., Pereira, Ana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407658/
https://www.ncbi.nlm.nih.gov/pubmed/35969759
http://dx.doi.org/10.1073/pnas.2108870119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407658/
https://www.ncbi.nlm.nih.gov/pubmed/35969759
http://dx.doi.org/10.1073/pnas.2108870119

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