Cargando…

Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

Tau protein aggregates are a major driver of neurodegeneration and behavioral impairments in tauopathies, including in Alzheimer’s disease (AD). Apolipoprotein E4 (APOE4), the highest genetic risk factor for late-onset AD, has been shown to exacerbate tau hyperphosphorylation in mouse models. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saroja, Sivaprakasam R., Gorbachev, Kirill, TCW, Julia, Goate, Alison M., Pereira, Ana C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407658/ https://www.ncbi.nlm.nih.gov/pubmed/35969759 http://dx.doi.org/10.1073/pnas.2108870119

Ejemplares similares

APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes
por: Lee, Sangderk, et al.
Publicado: (2023)

Astrocytic apoE4 and tau: Deadly combination for neurons
por: Chakrabarty, Paramita, et al.
Publicado: (2021)

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion
por: Plouffe, Vanessa, et al.
Publicado: (2012)

Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction
por: Ezerskiy, Lubov A., et al.
Publicado: (2022)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes
por: Keable, Abby, et al.
Publicado: (2020)

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation
por: Farhy-Tselnicker, Isabella, et al.
Publicado: (2017)

Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathology
por: Huang, Shichao, et al.
Publicado: (2022)

Glypican-1 drives unconventional secretion of fibroblast growth factor 2
por: Sparn, Carola, et al.
Publicado: (2022)

Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease
por: Pascoal, T A, et al.
Publicado: (2017)

MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
por: Cao, Jiqing, et al.
Publicado: (2020)

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses
por: Meng, Jonathan X., et al.
Publicado: (2022)

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
por: Melov, Simon, et al.
Publicado: (2007)

Hyperphosphorylated tau in young and middle-aged subjects
por: Elobeid, Adila, et al.
Publicado: (2011)

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
por: Ozdemir, Ahmet Yunus, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Immunological memory to hyperphosphorylated tau in asymptomatic individuals
por: Pascual, Gabriel, et al.
Publicado: (2017)

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated
por: Barthélemy, Nicolas R., et al.
Publicado: (2022)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

Astrocytic function is associated with both amyloid-β and tau pathology in non-demented APOE ϵ4 carriers
por: Spotorno, Nicola, et al.
Publicado: (2022)

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
por: Barron, Matthew R., et al.
Publicado: (2020)

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2016)

Heparan Sulfated Glypican-4 Is Released from Astrocytes by Proteolytic Shedding and GPI-Anchor Cleavage Mechanisms
por: Huang, Kevin, et al.
Publicado: (2021)

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
por: Duka, Valeriy, et al.
Publicado: (2013)

Identification of potent inhibitors of microtubule affinity regulating kinase for inhibition of tau hyperphosphorylation
por: Levy, Alison, et al.
Publicado: (2013)

Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation
por: Julien, Carl, et al.
Publicado: (2012)

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
por: Jung, Ga-young, et al.
Publicado: (2013)

Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
por: Liu, Jin, et al.
Publicado: (2016)

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
por: Wan, Wenbin, et al.
Publicado: (2019)

Corrigendum: Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2017)

Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease
por: Ivanov, Stefan M., et al.
Publicado: (2020)

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
por: Allen, Nicola J., et al.
Publicado: (2012)

Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid
por: Foidl, Bettina M., et al.
Publicado: (2018)

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes
por: Schmukler, Eran, et al.
Publicado: (2020)

APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes
por: Eran, Schmukler, et al.
Publicado: (2021)

CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer’s disease
por: Koch, Giacomo, et al.
Publicado: (2017)

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice
por: Zhang, Qing, et al.
Publicado: (2018)

Expression of Concern: Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
Publicado: (2023)

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques
por: Preman, Pranav, et al.
Publicado: (2021)

hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics
por: TCW, Julia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sk8jeg65rqh3p8vdf0ppt3476q