Inferring gene regulation from stochastic transcriptional variation across single cells at steady state

Regulatory relationships between transcription factors (TFs) and their target genes lie at the heart of cellular identity and function; however, uncovering these relationships is often labor-intensive and requires perturbations. Here, we propose a principled framework to systematically infer gene re...

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Detalles Bibliográficos
Autores principales: Gupta, Anika, Martin-Rufino, Jorge D., Jones, Thouis R., Subramanian, Vidya, Qiu, Xiaojie, Grody, Emanuelle I., Bloemendal, Alex, Weng, Chen, Niu, Sheng-Yong, Min, Kyung Hoi, Mehta, Arnav, Zhang, Kaite, Siraj, Layla, Al' Khafaji, Aziz, Sankaran, Vijay G., Raychaudhuri, Soumya, Cleary, Brian, Grossman, Sharon, Lander, Eric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407670/
https://www.ncbi.nlm.nih.gov/pubmed/35969771
http://dx.doi.org/10.1073/pnas.2207392119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407670/
https://www.ncbi.nlm.nih.gov/pubmed/35969771
http://dx.doi.org/10.1073/pnas.2207392119

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