TMAO Suppresses Megalin Expression and Albumin Uptake in Human Proximal Tubular Cells Via PI3K and ERK Signaling

Trimethylamine-N-oxide (TMAO) is a uremic toxin, which has been associated with chronic kidney disease (CKD). Renal tubular epithelial cells play a central role in the pathophysiology of CKD. Megalin is an albumin-binding surface receptor on tubular epithelial cells, which is indispensable for urine...

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Detalles Bibliográficos
Autores principales: Kapetanaki, Stefania, Kumawat, Ashok Kumar, Persson, Katarina, Demirel, Isak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407713/
https://www.ncbi.nlm.nih.gov/pubmed/36012119
http://dx.doi.org/10.3390/ijms23168856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9407713/
https://www.ncbi.nlm.nih.gov/pubmed/36012119
http://dx.doi.org/10.3390/ijms23168856

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