Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro

The teratogenic activity of valproate (VPA), an antiepileptic and an inhibitor of histone deacetylase (HDACi), is dose-dependent in humans. Previous results showed that VPA impairs in vitro development and neural differentiation of the gastrulating embryo proper. We aimed to investigate the impact o...

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Detalles Bibliográficos
Autores principales: Katušić-Bojanac, Ana, Plazibat, Milvija, Himelreich-Perić, Marta, Eck-Raković, Katarina, Krasić, Jure, Sinčić, Nino, Jurić-Lekić, Gordana, Ježek, Davor, Bulić-Jakuš, Floriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408494/
https://www.ncbi.nlm.nih.gov/pubmed/36012122
http://dx.doi.org/10.3390/ijms23168861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408494/
https://www.ncbi.nlm.nih.gov/pubmed/36012122
http://dx.doi.org/10.3390/ijms23168861

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