LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2

LHX2 dysregulations have been found to present in cancers, but the function of LHX2 in esophageal squamous cell carcinoma (ESCC) remains unknown. Here, we report that LHX2 was upregulated in ESCC tissues in comparison to the LHX2 levels in adjacent normal tissues. Loss- and gain-of-function experime...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xukun, Wu, Xueling, Chen, Hongyan, Liu, Zhihua, He, Huan, Wang, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408536/
https://www.ncbi.nlm.nih.gov/pubmed/36011368
http://dx.doi.org/10.3390/genes13081457
_version_ 1784774625405698048
author Li, Xukun
Wu, Xueling
Chen, Hongyan
Liu, Zhihua
He, Huan
Wang, Luhua
author_facet Li, Xukun
Wu, Xueling
Chen, Hongyan
Liu, Zhihua
He, Huan
Wang, Luhua
author_sort Li, Xukun
collection PubMed
description LHX2 dysregulations have been found to present in cancers, but the function of LHX2 in esophageal squamous cell carcinoma (ESCC) remains unknown. Here, we report that LHX2 was upregulated in ESCC tissues in comparison to the LHX2 levels in adjacent normal tissues. Loss- and gain-of-function experiments demonstrated that the knockdown of LHX2 markedly inhibited ESCC cells’ proliferation, migration, invasion, tumor growth and metastasis, whereas the overexpression of LHX2 had the opposite effects. A mechanistic investigation revealed that LHX2 bound to the promoter of SERPINE2 gene and transcriptionally regulated the expression of SERPINE2. Collectively, LHX2 facilitates ESCC tumor progression, and it could be a potential therapeutic target for ESCC.
format Online
Article
Text
id pubmed-9408536
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94085362022-08-26 LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2 Li, Xukun Wu, Xueling Chen, Hongyan Liu, Zhihua He, Huan Wang, Luhua Genes (Basel) Article LHX2 dysregulations have been found to present in cancers, but the function of LHX2 in esophageal squamous cell carcinoma (ESCC) remains unknown. Here, we report that LHX2 was upregulated in ESCC tissues in comparison to the LHX2 levels in adjacent normal tissues. Loss- and gain-of-function experiments demonstrated that the knockdown of LHX2 markedly inhibited ESCC cells’ proliferation, migration, invasion, tumor growth and metastasis, whereas the overexpression of LHX2 had the opposite effects. A mechanistic investigation revealed that LHX2 bound to the promoter of SERPINE2 gene and transcriptionally regulated the expression of SERPINE2. Collectively, LHX2 facilitates ESCC tumor progression, and it could be a potential therapeutic target for ESCC. MDPI 2022-08-16 /pmc/articles/PMC9408536/ /pubmed/36011368 http://dx.doi.org/10.3390/genes13081457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Xukun
Wu, Xueling
Chen, Hongyan
Liu, Zhihua
He, Huan
Wang, Luhua
LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2
title LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2
title_full LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2
title_fullStr LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2
title_full_unstemmed LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2
title_short LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2
title_sort lhx2 enhances the malignant phenotype of esophageal squamous cell carcinoma by upregulating the expression of serpine2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408536/
https://www.ncbi.nlm.nih.gov/pubmed/36011368
http://dx.doi.org/10.3390/genes13081457
work_keys_str_mv AT lixukun lhx2enhancesthemalignantphenotypeofesophagealsquamouscellcarcinomabyupregulatingtheexpressionofserpine2
AT wuxueling lhx2enhancesthemalignantphenotypeofesophagealsquamouscellcarcinomabyupregulatingtheexpressionofserpine2
AT chenhongyan lhx2enhancesthemalignantphenotypeofesophagealsquamouscellcarcinomabyupregulatingtheexpressionofserpine2
AT liuzhihua lhx2enhancesthemalignantphenotypeofesophagealsquamouscellcarcinomabyupregulatingtheexpressionofserpine2
AT hehuan lhx2enhancesthemalignantphenotypeofesophagealsquamouscellcarcinomabyupregulatingtheexpressionofserpine2
AT wangluhua lhx2enhancesthemalignantphenotypeofesophagealsquamouscellcarcinomabyupregulatingtheexpressionofserpine2

Ejemplares similares