Molecular Dynamic Simulation Reveals Structure Differences in APOL1 Variants and Implication in Pathogenesis of Chronic Kidney Disease

Background: According to observational studies, two polymorphisms in the apolipoprotein L1 (APOL1) gene have been linked to an increased risk of chronic kidney disease (CKD) in Africans. One polymorphism involves the substitution of two amino-acid residues (S342G and I384M; known as G1), while the o...

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Detalles Bibliográficos
Autores principales: Mayanja, Richard, Kintu, Christopher, Diabate, Oudou, Soremekun, Opeyemi, Oluwagbemi, Olugbenga Oluseun, Wele, Mamadou, Kalyesubula, Robert, Jjingo, Daudi, Chikowore, Tinashe, Fatumo, Segun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408642/
https://www.ncbi.nlm.nih.gov/pubmed/36011371
http://dx.doi.org/10.3390/genes13081460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408642/
https://www.ncbi.nlm.nih.gov/pubmed/36011371
http://dx.doi.org/10.3390/genes13081460

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