UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader

We previously reported that glucokinase is ubiquitinated and degraded by cereblon with an unknown endogenous glucokinase protein degrader. Here, we show that UDP-glucose is a glucokinase protein degrader. We identified that both glucose and UDP-glucose bind to glucokinase and that both uridine and U...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Jaeyong, Miyagawa, Atsushi, Yamaguchi, Kazuki, Abe, Wakana, Tsugawa, Yoji, Yamamura, Hatsuo, Imai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409010/
https://www.ncbi.nlm.nih.gov/pubmed/36012359
http://dx.doi.org/10.3390/ijms23169094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409010/
https://www.ncbi.nlm.nih.gov/pubmed/36012359
http://dx.doi.org/10.3390/ijms23169094

Ejemplares similares