The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation

Diabetic kidney disease (DKD) can cause inflammation and fibrosis, in addition to being the main complication of diabetes. Among many factors, epigenetic alterations in aberrant histone modifications play a key role in causing DKD. In this study, the mechanism of GSK-J4, a histone demethylase KDM6A...

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Detalles Bibliográficos
Autores principales: Hung, Peir-Haur, Hsu, Yung-Chien, Chen, Tsung-Hsien, Ho, Cheng, Lin, Chun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409090/
https://www.ncbi.nlm.nih.gov/pubmed/36012674
http://dx.doi.org/10.3390/ijms23169407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409090/
https://www.ncbi.nlm.nih.gov/pubmed/36012674
http://dx.doi.org/10.3390/ijms23169407

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