Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor

Heat shock protein 90 (Hsp90) is a ubiquitous molecular chaperone that stabilizes client proteins in a folded and functional state. It is composed of two identical and symmetrical subunits and each monomer consists of three domains, the N-terminal (NTD), the middle (MD), and the C-terminal domain (C...

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Detalles Bibliográficos
Autores principales: Tassone, Giusy, Mazzorana, Marco, Mangani, Stefano, Petricci, Elena, Cini, Elena, Giannini, Giuseppe, Pozzi, Cecilia, Maramai, Samuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409116/
https://www.ncbi.nlm.nih.gov/pubmed/36012721
http://dx.doi.org/10.3390/ijms23169458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409116/
https://www.ncbi.nlm.nih.gov/pubmed/36012721
http://dx.doi.org/10.3390/ijms23169458

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