Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington’s Disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder, of the so-called minority diseases, due to its low prevalence. It is caused by an abnormally long track of glutamines (polyQs) in mutant huntingtin (mHtt), which makes the protein toxic and prone to aggregation. Many path...

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Detalles Bibliográficos
Autores principales: Merino, Marián, Sequedo, María Dolores, Sánchez-Sánchez, Ana Virginia, Clares, Mª Paz, García-España, Enrique, Vázquez-Manrique, Rafael P., Mullor, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409211/
https://www.ncbi.nlm.nih.gov/pubmed/36012207
http://dx.doi.org/10.3390/ijms23168936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409211/
https://www.ncbi.nlm.nih.gov/pubmed/36012207
http://dx.doi.org/10.3390/ijms23168936

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