Characterization of Calpain and Caspase-6-Generated Glial Fibrillary Acidic Protein Breakdown Products Following Traumatic Brain Injury and Astroglial Cell Injury

Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells which is upregulated in traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic protease calpain to GFAP breakdown products (GBDP) of 46-...

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Detalles Bibliográficos
Autores principales: Yang, Zhihui, Arja, Rawad Daniel, Zhu, Tian, Sarkis, George Anis, Patterson, Robert Logan, Romo, Pammela, Rathore, Disa S., Moghieb, Ahmed, Abbatiello, Susan, Robertson, Claudia S., Haskins, William E., Kobeissy, Firas, Wang, Kevin K. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409281/
https://www.ncbi.nlm.nih.gov/pubmed/36012232
http://dx.doi.org/10.3390/ijms23168960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409281/
https://www.ncbi.nlm.nih.gov/pubmed/36012232
http://dx.doi.org/10.3390/ijms23168960

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