Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis

Background: The present study investigated whether angiotensin II type 1 receptor blocker irbesartan (ARB) and partial agonist of PPAR-γ prevents heart apoptosis by suppressing cardiac Fas/FasL-mediated to mitochondria-mediated apoptosis in the hearts of hypertensive rat model. Methods: Cardiac func...

Descripción completa

Detalles Bibliográficos
Autores principales: Pai, Pei-Ying, Wong, James K. S., Cui, Zhen-Yang, Lin, Yi-Yuan, Lee, Shin-Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409657/
https://www.ncbi.nlm.nih.gov/pubmed/36005430
http://dx.doi.org/10.3390/jcdd9080266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409657/
https://www.ncbi.nlm.nih.gov/pubmed/36005430
http://dx.doi.org/10.3390/jcdd9080266

Ejemplares similares