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Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis

Background: The present study investigated whether angiotensin II type 1 receptor blocker irbesartan (ARB) and partial agonist of PPAR-γ prevents heart apoptosis by suppressing cardiac Fas/FasL-mediated to mitochondria-mediated apoptosis in the hearts of hypertensive rat model. Methods: Cardiac func...

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Detalles Bibliográficos
Autores principales:	Pai, Pei-Ying, Wong, James K. S., Cui, Zhen-Yang, Lin, Yi-Yuan, Lee, Shin-Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409657/ https://www.ncbi.nlm.nih.gov/pubmed/36005430 http://dx.doi.org/10.3390/jcdd9080266

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