Tunicamycin-Induced Endoplasmic Reticulum Stress Damages Complex I in Cardiac Mitochondria

Background: Induction of acute ER (endoplasmic reticulum) stress using thapsigargin contributes to complex I damage in mouse hearts. Thapsigargin impairs complex I by increasing mitochondrial calcium through inhibition of Ca(2+)-ATPase in the ER. Tunicamycin (TUNI) is used to induce ER stress by inh...

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Detalles Bibliográficos
Autores principales: Chen, Qun, Thompson, Jeremy, Hu, Ying, Lesnefsky, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409705/
https://www.ncbi.nlm.nih.gov/pubmed/36013387
http://dx.doi.org/10.3390/life12081209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409705/
https://www.ncbi.nlm.nih.gov/pubmed/36013387
http://dx.doi.org/10.3390/life12081209

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