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Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices
Glioblastoma is the most common and aggressive primary brain tumor. Multiple genetic and epigenetic alterations in several major signaling pathways—including the phosphoinositide 3-kinases (PI3K)/AKT/mTOR and the Raf/MEK/ERK pathway—could be found. We therefore aimed to investigate the biological an...
Autores principales: | Hörnschemeyer, Julia, Kirschstein, Timo, Reichart, Gesine, Sasse, Christin, Venus, Jakob, Einsle, Anne, Porath, Katrin, Linnebacher, Michael, Köhling, Rüdiger, Lange, Falko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409734/ https://www.ncbi.nlm.nih.gov/pubmed/36013437 http://dx.doi.org/10.3390/life12081258 |
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