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κ-Opioid Receptor Agonist U50448H Protects Against Acute Lung Injury in Rats with Cardiopulmonary Bypass via the CAP-NLRP3 Signaling Pathway

OBJECTIVE: Acute lung injury (ALI) is one of the common and severe complications of cardiopulmonary bypass (CPB), which is the primary cause of death in intensive care units. Nevertheless, there is a lack of effective treatment for ALI secondary to CPB. κ-Opioid receptor (KOR) agonists have been dem...

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Detalles Bibliográficos
Autores principales: Gao, Guang-Jie, Song, Dan-Dan, Li, Long, Zhao, Fan, Sun, Ying-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410796/
https://www.ncbi.nlm.nih.gov/pubmed/36034965
http://dx.doi.org/10.1155/2022/2868135