SMG-6 mRNA cleavage stalls ribosomes near premature stop codons in vivo

Nonsense-mediated mRNA decay (NMD) protects cells from the toxic and potentially dominant effects of truncated proteins. Targeting of mRNAs with early stop codons is mediated by the ribosome and spatiotemporally aligned with translation termination. Previously we identified a novel NMD intermediate:...

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Detalles Bibliográficos
Autores principales: Kim, John H, Modena, Matthew S, Sehgal, Enisha, Courney, Annie, Neudorf, Celine W, Arribere, Joshua A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410879/
https://www.ncbi.nlm.nih.gov/pubmed/35950494
http://dx.doi.org/10.1093/nar/gkac681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410879/
https://www.ncbi.nlm.nih.gov/pubmed/35950494
http://dx.doi.org/10.1093/nar/gkac681

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