Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism

The use of multiple drugs simultaneously targeting DNA is a promising strategy in cancer therapy for potentially overcoming single drug resistance. In support of this concept, we report that a combination of actinomycin D (ActD) and echinomycin (Echi), can interact in novel ways with native and mism...

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Detalles Bibliográficos
Autores principales: Satange, Roshan, Kao, Shih-Hao, Chien, Ching-Ming, Chou, Shan-Ho, Lin, Chi-Chien, Neidle, Stephen, Hou, Ming-Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410880/
https://www.ncbi.nlm.nih.gov/pubmed/35871296
http://dx.doi.org/10.1093/nar/gkac629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410880/
https://www.ncbi.nlm.nih.gov/pubmed/35871296
http://dx.doi.org/10.1093/nar/gkac629

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