SRRM2 organizes splicing condensates to regulate alternative splicing

SRRM2 is a nuclear-speckle marker containing multiple disordered domains, whose dysfunction is associated with several human diseases. Using mainly EGFP-SRRM2 knock-in HEK293T cells, we show that SRRM2 forms biomolecular condensates satisfying most hallmarks of liquid-liquid phase separation, includ...

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Detalles Bibliográficos
Autores principales: Xu, Shaohai, Lai, Soak-Kuan, Sim, Donald Yuhui, Ang, Warren Shou Leong, Li, Hoi Yeung, Roca, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410892/
https://www.ncbi.nlm.nih.gov/pubmed/35929045
http://dx.doi.org/10.1093/nar/gkac669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410892/
https://www.ncbi.nlm.nih.gov/pubmed/35929045
http://dx.doi.org/10.1093/nar/gkac669

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