Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide

The diterpenoid triepoxides triptolide and triptonide from Tripterygium wilfordii (thunder god wine) exhibit unique bioactivities with potential uses in disease treatment and as a non-hormonal male contraceptives. Here, we show that cytochrome P450s (CYPs) from the CYP71BE subfamily catalyze an unpr...

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Detalles Bibliográficos
Autores principales: Hansen, Nikolaj Lervad, Kjaerulff, Louise, Heck, Quinn Kalby, Forman, Victor, Staerk, Dan, Møller, Birger Lindberg, Andersen-Ranberg, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411204/
https://www.ncbi.nlm.nih.gov/pubmed/36008399
http://dx.doi.org/10.1038/s41467-022-32667-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411204/
https://www.ncbi.nlm.nih.gov/pubmed/36008399
http://dx.doi.org/10.1038/s41467-022-32667-5

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