Cargando…
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes
Type 2 diabetes is an independent risk factor for non-alcoholic steatohepatitis (NASH) progression and its mediators have not been resolved. In this study, a pathogenic role of cellular communication network factor 2 (CCN2) protein in NASH pathology, was investigated in an established preclinical NA...
Autores principales: | Ren, Jing, Wang, Xiaoyu, Parry, Sarah N., Yee, Christine, Gorrell, Mark D., McLennan, Susan V., Twigg, Stephen M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411483/ https://www.ncbi.nlm.nih.gov/pubmed/35038159 http://dx.doi.org/10.1007/s12079-022-00667-1 |
Ejemplares similares
-
Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes
por: Wang, Xiaoyu, et al.
Publicado: (2010) -
Sitagliptin Is More Effective Than Gliclazide in Preventing Pro-Fibrotic and Pro-Inflammatory Changes in a Rodent Model of Diet-Induced Non-Alcoholic Fatty Liver Disease
por: Ren, Jing, et al.
Publicado: (2022) -
Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing
por: Henshaw, F. R., et al.
Publicado: (2015) -
The effects of high-fat feeding on physical function and skeletal muscle extracellular matrix
por: Tam, C S, et al.
Publicado: (2015) -
CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis
por: Ju, Linling, et al.
Publicado: (2020)