OPN inhibits autophagy through CD44, integrin and the MAPK pathway in osteoarthritic chondrocytes

BACKGROUND: To investigate whether osteopontin (OPN) affects autophagy in human osteoarthritic chondrocytes and determine the roles of CD44, αvβ3 integrin and the Mitogen-activated protein kinase (MAPK) pathway in this progress. METHODS: First, we compared the autophagy levels in the human osteoarth...

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Detalles Bibliográficos
Autores principales: Bai, Rui-Jun, Liu, Di, Li, Yu-Sheng, Tian, Jian, Yu, Deng-Jie, Li, Heng-Zhen, Zhang, Fang-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411521/
https://www.ncbi.nlm.nih.gov/pubmed/36034459
http://dx.doi.org/10.3389/fendo.2022.919366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411521/
https://www.ncbi.nlm.nih.gov/pubmed/36034459
http://dx.doi.org/10.3389/fendo.2022.919366

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