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Ginsenoside Rg5 allosterically interacts with P2RY(12) and ameliorates deep venous thrombosis by counteracting neutrophil NETosis and inflammatory response
BACKGROUND: Deep venous thrombosis (DVT) highly occurs in patients with severe COVID-19 and probably accounted for their high mortality. DVT formation is a time-dependent inflammatory process in which NETosis plays an important role. However, whether ginsenoside Rg5 from species of Panax genus could...
Autores principales: | Chen, Ziyu, Wang, Gaorui, Xie, Xueqing, Liu, Heng, Liao, Jun, Shi, Hailian, Chen, Min, Lai, Shusheng, Wang, Zhengtao, Wu, Xiaojun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411522/ https://www.ncbi.nlm.nih.gov/pubmed/36032109 http://dx.doi.org/10.3389/fimmu.2022.918476 |
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